The 2016 Nobel Prize Awarded to Autophagy Research

 

Autophagy: How “Self-Cleaning” Cells Are Key to Curing Disease

Japanese scientist Yoshinori Ohsumi just won the 2016 Nobel Prize in Physiology or Medicine “for his discoveries of mechanisms for autophagy.” Autophagy, derived from the Greek, literally means “self-eating.”

Wall Street Daily: Wed, Oct 12, 2016 | David Dittman, Editorial Director

History of Biophagy: Highlights

 

  • 2012: Founded by Stuart Rose (IP: Vojo Deretic, UNM)
  • 2013: Joined: Mary Ortner, Steven Bradfute
  • 2013: Individual NMSBA Grant Awarded: Work with Sandia National Laboratories
  • 2014: Secured Additional IP from STC.UNM: TRIM, neutral lipids, and additional compounds
  • 2014: Individual NMSBA Grant Awarded: Work with Sandia National Laboratories
  • 2015: Individual NMSBA Grant Awarded: Work with Sandia National Laboratories
  • 2016: Patent Awarded: Seven drug combinations that stimulate autophagy
  • 2016: Leverage Grant Awarded: NMSBA Leverage Grant with Sandia National Laboratories
  • 2016: Co-investment Funding (2016) Awarded: University New Mexico
  • 2017: Joined: Ian Henderson
  • 2017: POC Established in TB
  • 2017: First Patents Filed on Proprietary Compounds
  • 2017: Leverage Grant Awarded (2017) NMSBA Leverage Grant with Sandia National Laboratories

Scientific Literature

Autophagy: molecular mechanisms and disease outcomes
Daniel J. Klionsky and Vojo Deretic
During autophagy, double-membrane structures called autophagosomes engulf cytosol or organelles and deliver them to lysosomes (in mammalian cells) or the vacuole …

How Cell Clean House
Daniel J. Klionsky and Vojo Deretic
Worn-out proteins, malfunctioning organelles, invading microorganisms: all are swept up by tiny internal “vacuum cleaners” that keep a living cell healthy. If the process, called autophagy, can be …

Autophagy in Human Health and Disease
Augustine M.K. Choi, M.D., Stefan W. Ryter, Ph.D., and Beth Levine, M.D.
Worn-out proteins, malfunctioning organelles, invading microorganisms: all are swept up by tiny internal “vacuum cleaners” that keep a living cell healthy. If the process, called autophagy, can be …

 

Autophagy: for better or for worse
Ellen Wirawan, Tom Vanden Berghe, Saskia Lippens, Patrizia Agostinis, Peter Vandenabeele
Cells have mechanisms that clear out superfluous, misfolded, damaged and harmful proteins: the ubiquitinproteasome degradation pathway and autophagy …

Autophagy Journals
Editor-in-Chief: Daniel J. Klionsky
Guidelines for the use and interpretation of assays for monitoring autophagy …

Autophagy: The Higgs Particle of Biology?
drugbaron
With all the excitement surrounding the discovery of a particle that might be the elusive Higgs Boson this week, it set DrugBaron wondering what might be the equivalent in biology …